Urotensin II-induced increase in myocardical distensibility is modulated by angiotensin II and endothelin-1

Title:

Urotensin II-induced increase in myocardical distensibility is modulated by angiotensin II and endothelin-1

Creator:

Fontes-Sousa, A. P., Pires, A. L., Monteiro-Cardoso, V. F., and Leite-Moreira, A. F.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6010b317-ce2d-4ec4-baa6-950f72382cb4
uuid:6010b317-ce2d-4ec4-baa6-950f72382cb4

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, myokard, physiology, myocardium, urotesin II, angiotensin II, endothelin-1, myocardial distensibility, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Endogenous regulators, such as angiotensin-II (AngII), endothelin-1 (ET-1) and urotensin-II (U-II) are released from various cell types and their plasma levels are elevated in several cardiovascular diseases. The present study evaluated a potential crosstalk between these systems by investigating if the myocardial effects of U-II are modulated by AngII or ET-1. Effects of U-II (10-8 , 10 -7 , 10 -6 M) were tested in rabbit papillary muscles in the absence and in the presence of losartan (selective AT1 receptor antagonist), PD-145065 ( nonselective ET-1 receptors antagonist), losartan plus PD-145065, AngII or ET-1. U-II promoted concentration-dependent negative inotropic and lusitropic effects that were abolished in all experimental conditions. Also, U-II increased resting muscle length up to 1.008±0.002 L/Lmax. Correcting it to its initial value resulted in a 19.5±3.5 % decrease of resting tension, indicating increased muscle distensibility. This effect on muscle length was completely abolished in the presence of losartan and significantly attenuated by PD-145065 or losartan plus PD-145065. This effect was increased in the presence of AngII, resulting in a 27.5±3.9 % decrease of resting tension, but was unaffected by the presence of ET-1. This study demonstrated an interaction of the U-II system with the AngII and ET-1 systems in terms of regulation of systolic and diastolic function., A. P. Fontes-Sousa ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false