Excitotoxicity of Lathyrus sativus neurotoxin in leech retzius neurons

Title:

Excitotoxicity of Lathyrus sativus neurotoxin in leech retzius neurons

Creator:

Cemerikic, D., Nedeljkov, V., Lopicic, S., Dragovic, S., and Beleslin, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5b60b18f-5a5f-45ba-bad4-ad097fb4c43a
uuid:5b60b18f-5a5f-45ba-bad4-ad097fb4c43a
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, input membrane resistance, intracellular Ca2+ concentration, intracellular Na+ and K+ activities, Lathyrus sativus excitotoxicity, leech retzius neurons, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of Lathyrus sativus neurotoxin were studied on the cell membrane potential and cellular cation composition in Retzius nerve cells of the leech Haemopis sanguisuga, with ion-selective microelectrodes using liquid ion-exchangers. Bath application of 10-4 mol/l Lathyrus sativus neurotoxin for 3 min depolarized the cell membrane potential and decreased the input resistance of directly polarized membrane in Retzius neurons. At the same time the cellular Na+ activity increased and cellular K+ activity decreased with slow but complete recovery, while the intracellular Ca2+ concentration was not changed. Na+-free Ringer solutions inhibited the depolarizing effect of the neurotoxin on the cell membrane potential. Zero-Ca2+ Ringer solution or Ni2+-Ringer solution had no influence on the depolarizing effect of the neurotoxin on the cell membrane potential. It is obvious that the increase in membrane conductance and depolarization of the cell membrane potential are due to an influx of Na+ into the cell accompanied by an efflux of K+ from the cell., D. Cemerikić, V. Nedeljkov, S. Lopičić, S. Dragović, B. Beleslin., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:2

Harvested from:

CDK

Metadata only:

false