Association of the -344T/C aldosterone synthase gene variant with essential hypertension

Title:

Association of the -344T/C aldosterone synthase gene variant with essential hypertension

Creator:

Zuzana Hlubocká, Marie Jáchymová, Samuel Heller, Věra Umnerová, Vilém Danzig, Věra Lánská, Karel Horký, and Aleš Linhart

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:599287fd-ff93-4634-96c2-6313a7029af7
uuid:599287fd-ff93-4634-96c2-6313a7029af7

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, hypertenze, polymorfismus, physiology, hypertension, polymorphism, aldosteron, aldosteron synthase, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. We therefore studied the association of -344T/C polymorphism of the CYP11B2 gene with the presence and severity of hypertension in a case-control study. We studied 369 individuals, of whom 213 were hypertensive patients (139 controlled hypertensive, 74 resistant hypertensive) and 156 were healthy normotensive subjects. The -344T/C polymorphism of the CYP11B2 gene was determined using polymerase chain reaction - restriction fragment length polymorphism analysis. The distribution of genotypes in normotensive controls and hypertensive subjects were: TT 25.6 vs. 31.9 %, TC 51.9 vs. 57.3 % and CC 22.4 vs. 10.8 %. The -344T/C variant was associated with hypertension. Subjects carrying the -344T allele had a greater risk of hypertension compared to those having C allele (χ2=5.89, p<0.05). The frequency of CC genotype was significantly lower in hypertensive patients than in normotensive controls ( χ2=9.44, p<0.01). A stepwise logistic regression analysis confirmed these findings. We did not find an association of -344T/C variant with the resistance of hypertensive patients to combination therapy, but we observed an association of -344T/C polymorphism of aldosterone synthase gene with increased risk of hypertension. These results support a potential role of -344T/C CYP11B2 gene polymorphism in genetic predisposition to develop hypertension., Z. Hlubocká ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:6

Harvested from:

CDK

Metadata only:

false