The importance of age and statin therapy in the interpretation of Lp-PLA2 in ACS patients, and relation to CRP

Title:

The importance of age and statin therapy in the interpretation of Lp-PLA2 in ACS patients, and relation to CRP

Creator:

Janka Franeková, Jiří Kettner, Kubíček, Z., and Antonín Jabor

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:58b7ef2d-c4f4-4048-9415-b5cb37ba88ca
uuid:58b7ef2d-c4f4-4048-9415-b5cb37ba88ca
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, biologické markery, akutní koronární syndromy, biological markers, acute coronary syndromes, plaque, atherosclerotic, c-reactive protein, phospholipase A2, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A2 (Lp-PLA2) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA2, and to assess the influence of statins on interpretation of Lp-PLA2. A total of 362 consecutive patients presenting to the emergency department (ED) with acute chest pain suggestive of ACS were evaluated by cardiologists as STEMI, NSTEMI, or unstable angina, and non- ACS. Serum biomarkers measured on admission: troponin I, Creactive protein (Abbott), and Lp-PLA2 (DiaDexus). Four groups were defined according to the final diagnos-; non- ACS/statin+. Lp-PLA2 was highest in ACS/statin- group; statins decreased Lp-PLA2 both in ACS and non-ACS of about 20 %. Lp- PLA2 was higher in ACS patients in comparison with non-ACS patients group without respect to statin therapy (p<0.001). Lp- PLA2 predicted worse outcome (in terms of acute coronary syndrome) effectively in patients up to 62 years; limited prediction was found in older patients. C-reactive protein (CRP) failed to discriminate four groups of patients. Statin therapy and age should be taken into consideration while interpreting Lp-PLA2 concentrations and lower cut-off values should be used for statintreated persons., J. Franeková, J. Kettner, Z. Kubíček, A. Jabor., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:2

Harvested from:

CDK

Metadata only:

false