Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat

Title:

Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat

Creator:

Trnovská, J., Šilhavý, J., Václav Zídek, Miroslava Šimáková, Petr Mlejnek, Vladimír Landa, Eigner, S., Eigner Henke, K., Škop, V., Olena Oliyarnyk, Lazdová, L., Tomáš Mráček, Josef Houštěk, and Michal Pravenec

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5696fa07-d19c-4341-bf16-1b7cccc65946
uuid:5696fa07-d19c-4341-bf16-1b7cccc65946
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, gender, metabolismus, metabolism, hairless rat, brown adipose tissue, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Cold exposure of rats leads to ameliorated glucose and triglyceride utilization with fema les displaying better adaptation to a cold environment. In the current study, we used hairless rats as a model of increased thermo genesis and analyzed gender- related effects on parameters of lipid and glucose metabolism in the spontaneously hypertensive (SHR) rats. Specifically, we compared hairless coisogenic SHR- Dsg4 males and females harboring mutant Dsg4 (desmoglein 4) gene versus their SHR wild type controls. Two way ANOVA showed significant Dsg4 genotype (hairless or wild type) x gender interaction effects on palmitate oxidation in brown adipose tissue (BAT), glucose incorporation into BAT determined by microPET, and glucose oxidation in skeletal muscles. In addition, we observed significant interaction effects on sensitivity of muscle tissue to insulin action when Dsg4 genotype affected these metabolic traits in males, but had little or no effects in females. Both wild type and hairless females and hairless males showed increased glucose incorporation and palmitate oxid ation in BAT and higher tissue insulin sensitivity when compared to wild type males. These findings provide evidence for gender-related differences in metabolic adaptation required for increased thermogenesis. They are consistent with the hypothesis that increased glucose and palmitate utilization in BAT and muscle is associated with higher sensitivity of adipose and muscle tissues to insulin action, J. Trnovská, J. Šilhavý, V. Zídek, M. Šimáková, P. Mlejnek, V. Landa, S. Eigner, K. Eigner Henke, V. Škop, O. Oliyarnyk, L. Kazdová, T. Mráček, J. Houštěk, M. Pravenec., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:1

Harvested from:

CDK

Metadata only:

false