Responses of skeletal muscle hypertrophy in Wistar rats to different resistance exercise models

Title:

Responses of skeletal muscle hypertrophy in Wistar rats to different resistance exercise models

Creator:

Luciano, T. F., Marques, S. O., Pieri, B. L., Souza, D. R. de, Araújo, L. V., Nesi, R. T., Scheffer, D. L., Comin, V. H., Pinho, R. A., Souza, C. T. de, and Muller, A. P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:565374aa-05d3-4f2a-95e2-f6fbb58d0b0c
uuid:565374aa-05d3-4f2a-95e2-f6fbb58d0b0c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, svaly, muscles, hypertrophy, mTOR phosphorylation, skeletal muscle, strength, hypertrophy training, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This study aimed to compare the effects of three different resistance exercise models on the quadriceps muscle crosssectional area, as well as on mTOR phosphorylation and other pivotal molecules involved in the upstream regulation of mTOR. Twenty-four male Wistar rats were divided into untrained (control), endurance resistance training, strength resistance training, and hypertrophy resistance training (HRT) groups (n=6). After 12 weeks of training, the red portion of the quadriceps was removed for histological and Western blot analyses. The results showed that the quadriceps weight and cross-sectional areas in the exercised groups were higher than those of the untrained rats. However, the HRT group presented better results than the other two experimental groups. This same pattern was observed for mTOR phosphorylation and for the most pivotal molecules involved in the upstream control of mTOR (increase of PKB, 14-3-3, ERK, p38 MAPK, and 4E-BP1 phosphorylation, and reduction of tuberin, sestrin 2, REDD1, and phospho AMPK). In summary, our study showed that HRT leads to high levels of mTOR phosphorylation as well as of other proteins involved in the upstream regulation of mTOR., T. F. Luciano, S. O. Marques, B. L. Pieri, D. R. de Souza, L. V. Araújo, R. T. Nesi, D. L. Scheffer, V. H. Comin, R. A. Pinho, A. P. Muller, C. T. de Souza., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:2

Harvested from:

CDK

Metadata only:

false