Influence of low-dose neonatal domoic acid on the spontaneous behavior of rats in early adulthood

Title:

Influence of low-dose neonatal domoic acid on the spontaneous behavior of rats in early adulthood

Creator:

Kateřina Jandová, Petr Kozler, Miloš Langmeier, Dana Marešová, Pokorný, J., and Vladimír Riljak

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5606d2aa-f332-436e-b902-21a0c53b7305
uuid:5606d2aa-f332-436e-b902-21a0c53b7305
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, domoic acid, locomotor activity, open field test, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Consumption of seafood containing toxin domoic acid (DA) causes an alteration of glutamatergic signaling pathways and could lead to various signs of neurotoxicity in animals and humans. Neonatal treatment with domoic acid was suggested as valuable model of schizophrenia and epilepsy. We tested how repeated early postnatal DA administration influences the spontaneous behavior of rats in adulthood. Rats were injected with 30 μg DA/kg from postnatal day (PND) 10 until PND 14. Their behavior was observed in the open field test for one hour (Laboras, Metris) at PND 35, PND 42 and PND 112. We did not find any difference between DA treated rats and animals injected with equivalent volume of saline in both test sessions at PND 35 and PND 42. DA rats at PND 112 exhibited significantly higher vertical and horizontal exploratory activity (tested parameters: locomotion, distance travelled, average speed reached during test, grooming and rearing) between the 30th-40th min of the test session and habituated over 10 min later. We conclude that at least in the given experimental design, neonatal DA treatment results in alteration of the spontaneous behavior of rats in adulthood., K. Jandová, P. Kozler, M. Langmeier, D. Marešová, J. Pokorný, V. Riljak., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false