Subdiabetogenic streptozocin treatment impairs preimplantation development of mouse embryos

Title:

Subdiabetogenic streptozocin treatment impairs preimplantation development of mouse embryos

Creator:

Veselá, J., Rehák, P., Baran, V., and Koppel, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5522f03b-72d5-4f8b-9b90-c769657e1add
uuid:5522f03b-72d5-4f8b-9b90-c769657e1add

Subject:

subdiabetic state, pregnancy, preimplantation embryo, development, and insulin

Type:

article, model:article, and TEXT

Description:

To estimate the significance of insulin in the regulation of preimplantation embryo growth, female mice received a single subdiabetogenic dose of streptozocin (65 mg/kg intraperitoneally) 8-11 days or 14-17 days before fertilization. Mean glycaemia levels and the number of embryos per mouse did not differ significantly between the streptozocin-treated and control groups. Morphological analysis of preimplantation embryos collected on day 3 of pregnancy revealed significant changes in the distribution pattern of preimplantation embryo stages recovered from streptozocin-treated females. Continuous insulin treatment of streptozocin-treated mice improved the impaired development of preimplantation embryos only in short-lasting experiments. After a long subdiabetic period (14-17 days) the incidence of degenerated embryos was increased in both streptozocin-treated groups. It can be concluded that the subdiabetic state in female mice impairs preimplantation embryo development which could partly be prevented by insulin treatment.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:1

Harvested from:

CDK

Metadata only:

false