Contemporary activation of different endothelial receptors accounts for a reserve mechanism of nitric oxide-mediated relaxation

Title:

Contemporary activation of different endothelial receptors accounts for a reserve mechanism of nitric oxide-mediated relaxation

Creator:

Kyselá, S. and Török, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:54a217e3-a51c-490f-b189-4d3d455c98b8
uuid:54a217e3-a51c-490f-b189-4d3d455c98b8
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, relaxace, acetylcholin, histamin, adenosin, oxid dusnatý, relaxation, acetylcholine, histamine, adenosine, nitric oxide, pulmonary artery, clonidine, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to investigate whether the inhibition of one of the endothelial receptor sites in the rat pulmonary artery (muscarinic, histaminergic, purinergic, a 2-adrenergic) affects the NO-mediated relaxation induced by the activation of the other type of receptors. Acetylcholine (ACh)-, histamine (Hist)-, adenosine (Ade)- , and clonidine (Clon)-induced endothelium-dependent relaxations were reduced by the administration of specific antagonists of muscarinic, H1-histaminergic, purinergic or a 2-adrenergic receptors, respectively. The inhibition of H1-histaminergic receptors by chlorphenyramine did not prevent ACh-induced relaxation. Similarly, the inhibition of muscarinic receptors by atropine did not prevent the relaxations to histamine, adenosine and clonidine. On the other hand, the relaxations induced by acetylcholine, histamine, adenosine or clonidine were regularly reduced by NO-synthase inhibitor NG-nitro-L-arginine methyl ester (10-4 mol/l). These results suggest that the inhibition of NO-synthase abolished arterial relaxations induced by all agonists. After inhibition of one type of the endothelial receptors, the NO-dependent relaxation could still be evoked by activation of one of the others., S. Kyselá, J. Török., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:1

Harvested from:

CDK

Metadata only:

false