The increase in cAMP and cGMP levels in the oestrogenized rat hypophysis

Title:

The increase in cAMP and cGMP levels in the oestrogenized rat hypophysis

Creator:

Nedvídková, J. and Schreiber, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5305a114-e812-4f2b-9887-d4ec31dcddd4
uuid:5305a114-e812-4f2b-9887-d4ec31dcddd4

Subject:

oestradiol, hypophysis, sodium nitroprusside, cAMP, cGMP, and prolactin

Type:

article, model:article, and TEXT

Description:

Male and female rats were given oestradiol benzoate (1 mg s.c. twice a week for 3 weeks) and/or sodium nitroprusside (SN), a donor of nitric oxide (NO), which was administered in their food in amounts of 0.2 or 0.6 mg/rat/day. Neither oestradiol-induced hypertrophy of the hypophysis, nor the serum prolactin (PRL) level, was affected by the simultaneous administration of SN. The PRL content of the hypophysis rose after oestradiol in the males, but the increase was again uninfluenced by the simultaneous administration of SN and the cAMP content of the hypophysis - raised after oestradiol - was likewise unaffected. The amount of cGMP in the hypophysis after oestradiol rose only in males. Both the serum and the hypophyseal prolactin level were found to be correlated to the cAMP and the cGMP content of the hypophysis. It was found that the simultaneous administration of SN together with oestradiol slightly reduced the increase in the cGMP content of the hypophysis elicited with oestradiol treatment only.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:4

Harvested from:

CDK

Metadata only:

false