Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R)

Title:

Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R)

Creator:

Hainer, Vojtěch, Aldhoon Hainerová, Irena, Kunešová, Marie, Braunerová, Radka, Zamrazilová, Hana, and Bendlová, Běla

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:52e95225-1542-4c27-adfb-82837a8ec122
uuid:52e95225-1542-4c27-adfb-82837a8ec122
issn:0862-8408
doi:10.33549/physiolres.934512

Subject:

obezita, obesity, MC4R agonists, melanocortin-4 receptor (MC4R) function, monogenic obesity, common obesity, gene polymorphisms, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance regulation. This review presents phenotypical characterization and prevalence of the MC4R gene mutations. Genome-wide association studies revealed that MC4R gene is significantly related not only to monogenic obesities but also to common obesity. An interaction of variants in the MC4R gene with fat mass and obesity associated (FTO) gene significantly increases the risk for obesity, particularly in adolescence. On the other hand, about 15 % of the MC4R gene variants result in a gain of function that protects against obesity and is associated with favorable metabolic profile. Long-term attempts to activate the MC4R have recently been finalized by a discovery of setmelanotide, a novel specific MC4R agonist that is devoid of untoward cardiovascular side-effects. The employment of specific MC4R agonists may open new horizons not only in the treatment of rare monogenic obesities but also in some common obesities where stimulation of MC4R could be achieved., Vojtěch Hainer, Irena Aldhoon Hainerová, Marie Kunešová, Radka Taxová Braunerová, Hana Zamrazilová, Běla Bendlová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S245-S254

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false