Endothelial dysfunction in femoral artery of the hypertensive rats is nitric oxide independent

Title:

Endothelial dysfunction in femoral artery of the hypertensive rats is nitric oxide independent

Creator:

Angelika Púzserová, Kopincová, J., Peter Slezák, Bališ, P., and Bernátová, I.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4f7cf88f-a75c-44ea-b210-a0a50c68ad3d
uuid:4f7cf88f-a75c-44ea-b210-a0a50c68ad3d

Subject:

Fyziologie člověka a srovnávací fyziologie, acetylcholin, endotel, acetylcholine, endothelium, borderline hypertension, SHR, vascular reactivity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

This study examined nitric oxide (NO) production, oxidative load and endothelium-dependent rela xation (NO-depe ndent and NO-independent) in adult male borderline hypertensive (BHR) and spontaneously hypertensive (S HR) rats as compared to normotensive Wistar-Kyoto (WKY) rats. Systolic blood pressure (BP) was determined by tail-cuff. NO production was determined by conversion of [3 H]-L-arginine. Conjugated dienes (CD) and concentrations of thiobarbituric acid-reactive substances (TBARS) were measured for assessment of oxidative load. Vascular function was investigated in ri ngs of the femoral artery (FA) using a wire myograph. BP of WKY, BHR and SHR was 106 ± 2, 143 ± 3 and 191 ± 3 mm Hg, respectively (p<0.01 for each). Significant left ventricle (LV) hy pertrophy and elevated levels of CD and TBARS in the LV were present in BHR and SHR as compared to WKY. NO production was elevated significantly in the aorta of BHR and SHR vs. WKY as well as in the LV of SHR vs. WKY. Acetylcholine (ACh)-induced relaxation of the FA was reduced significantly in both BHR and SHR vs. WKY. The NO-dependent component of ACh-induced relaxation had increasing tendency in hypertensive groups and it correlated positively with BP. The NO-independent component of vasorelaxation was reduced significantly in BHR and SHR vs. WKY and it correlated negatively with BP. In conclusion, the results showed that endothelial dysfunction in the experimental model of borderline hypertensive and hypertensive rats is NO-independent. The results suggest that borderline hypertension represents a risk of other cardiovascular disorders wh ich is qualitatively similar to that of fully developed hypertension., A. Púzserová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:6

Harvested from:

CDK

Metadata only:

false