Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle pattern versus troponin T determination

Title:

Early detection of anthracycline cardiotoxicity in a rabbit model: left ventricle pattern versus troponin T determination

Creator:

Martin Štěrba, Tomáš Šimůnek, Popelová, O., Anna Potáčová, Michaela Adamcová, Yvona Mazurová, Magdalena Holečková, and Vladimír Geršl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4f500787-21c6-47da-8167-bf5b8629d44d
uuid:4f500787-21c6-47da-8167-bf5b8629d44d
issn:0862-8408

Subject:

Biochemie. Molekulární biologie. Biofyzika, fyziologie, kardiotoxicita, troponiny, physiology, cardiac toxicity, troponins, daunorubicin, anthracyclines, early detection, diastolic dysfunction, cardiac troponin T, 2, and 577

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Anthracycline cardiotoxicity represents a serious risk of anticancer chemotherapy. The aim of the present pilot study was to compare the potential of both the left ventricular (LV) filling pattern evaluation and cardiac troponin T (cTnT) plasma levels determination for the early detection of daunorubicin-induced cardiotoxicity in rabbits. The echocardiographic measurements of transmitral LV inflow as well as cTnT determinations were performed weekly for 10 weeks in daunorubicin (3 mg/kg weekly) and control groups (n=5, each). Surprisingly, no significant changes in LV-filling pattern were observed through the study, most likely due to the xylazine-containing anesthesia, necessary for appropriate resolving of the E and A waves. In contrast to the echographic measurement, the dP/dt min index obtained invasively at the end of the study revealed a significant im pairment in LV relaxation, which was further supported by observed disturbances in myocardial collagen content and calcium homeostasis. However, at the same time cTnT plasma levels were progressively rising in the daunorubicin-treated animals from the 5th week (0.024±0.008 μg/l) until the end of the experiment (0.186±0.055 μg/l). Therefore, in contrast to complicated non-invasive evaluation of diastolic function, cTnT is shown to be an early and sensitive marker of anthracycline-induced cardiotoxicity in the rabbit model., M. Štěrba, T. Šimůnek, O. Popelová, A. Potáčová, M. Adamcová, Y. Mazurová, M. Holečková, V. Geršl., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:5

Harvested from:

CDK

Metadata only:

false