Ontogenetic development of sensitivity of the cerebral cortex to an Antagonist of GABAA receptor bicuculline

Title:

Ontogenetic development of sensitivity of the cerebral cortex to an Antagonist of GABAA receptor bicuculline

Creator:

Pavel Mareš, Klára Bernášková, and Hana Kubová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4e59c07e-cfab-4627-aa6c-35a6b0d2d1db
uuid:4e59c07e-cfab-4627-aa6c-35a6b0d2d1db
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Cerebral cortex, Rat, Postnatal development, Epileptic phenomena, Bicuculline, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Local application of four concentrations of bicuculline methiodide (a specific antagonist of GABAA receptors) was used to study a sensitivity of somatosensory cortex in four age groups of immature rats with implanted electrodes. Presence and latencies of two epileptic phenomena (focal discharges and seizures) were evaluated. Focal discharges exhibited moderate tendency to a decrease of sensitivity to bicuculline methiodide with maturation. Concentration-effect relation of incidence of focal discharges was observed only in 7- and 12-day-old but not in older animals. Results with incidence and latencies of seizures did not show relations to age or concentration of bicuculline. Neither of the epileptic phenomena can be used as a reliable index of cortical maturation., P. Mareš, K. Bernášková, H. Kubová., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:1

Harvested from:

CDK

Metadata only:

false