Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats

Title:

Changes in hind paw epidermal thickness, peripheral nerve distribution and mechanical sensitivity after immobilization in rats

Creator:

Nakano, J., Sekino, Y., Hamaue, Y., Sakamoto, J., Yoshimura, T., Origuchi, T., and Okita, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4bc0b1db-2550-4a14-b7e3-23454ecafb12
uuid:4bc0b1db-2550-4a14-b7e3-23454ecafb12

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, immobilization, hypersensitivity, skin, epidermal thickness, peripheral nerve, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

This study was designed to investigate histological changes in skin tissue accompanying immobilization-induced hypersensitivity. Changes in mechanical sensitivity, epidermal thickness, and peripheral nerve profiles in the upper dermis were examined in glabrous skin of rat hind paw after 1, 2, and 4 weeks of ankle joint immobilization by plaster casts. Induction of mechanical hypersensitivity was confirmed after 2 and 4 weeks of joint immobilization. Epidermal thinning and increase in peripheral nerve profiles were observed in skin tissues in immobilized rats. The time course of epidermal thinning and increase in peripheral nerve profiles were similar closely to that of hypersensitivity, with significant differences between the immobilized and control rats after 2 weeks of immobilization, which became even more remarkable at 4 weeks of immobilization. These findings suggest that joint immobilization by cast induces epidermal thinning and increases peripheral nerve profiles in the upper dermis and that these changes might be partly responsible for immobilization-induced hypersensitivity., J. Nakano, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:6

Harvested from:

CDK

Metadata only:

false