GFP transgenic animals in biomedical research: a review of potential disadvantages

Title:

GFP transgenic animals in biomedical research: a review of potential disadvantages

Creator:

Lipták, N. , Bősze, Z., and Hiripi, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4b351ccf-9020-4c69-9b62-b0f2165a4a69
uuid:4b351ccf-9020-4c69-9b62-b0f2165a4a69
doi:10.33549/physiolres.934227

Subject:

GFP, transgenic animals, glomerulosclerosis, and dilated cardiomyopathy

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals’ health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

525-530

Source:

Physiological research | 2019 Volume:68 | Number:4

Harvested from:

CDK

Metadata only:

false