Changes to fetal steroidogenesis caused by maternal smoking

Title:

Changes to fetal steroidogenesis caused by maternal smoking

Creator:

Adamcová, K., Lucie Kolátorová Sosvorová, Chlupáčová, T., Šimková, M., Jandíková, H., Antonín Pařízek, Luboslav Stárka, and Michaela Dušková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4b275757-7857-463a-839c-4afe5b424557
uuid:4b275757-7857-463a-839c-4afe5b424557
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, novorozenci, testosteron, kouření, těhotenství, newborns, testosterone, smoking, pregnancy, dehydroepiandrosterone metabolites, smoking in pregnancy, delivery, androstenedione, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Smoking during pregnancy presents health risks for both the mother and her child. In this study we followed changes in the production of steroid hormones in pregnant smokers. We focused on changes in steroidogenesis in the blood of mothers in their 37th week of pregnancy and in mixed cord blood from their newborns. The study included 88 healthy women with physiological pregnancies (17 active smokers and 71 nonsmokers). We separately analyzed hormonal changes associated with smoking according to the sex of newborns. In women with male fetuses, we found higher levels of serum cortisone, dehydroepiandrosterone (DHEA), 7α-OH-DHEA, 17-OH pregnenolone, testosterone, and androstenedione in smokers at the 37th week compared to non-smokers. In women with female fetuses, we found lower serum levels of 7β-OH-DHEA and higher androstenedione in smokers at the 37th week. We found significantly higher levels of testosterone in newborn males of smokers and higher levels of 7α-OH-DHEA in female newborns of smokers. Smoking during pregnancy induces changes in the production of steroids in both the mother and her child. These changes are different for different fetal sexes, with more pronounced changes in mothers carrying male newborns as well as in the newborn males themselves., K. Adamcová, L. Kolátorová, T. Chlupáčová, M. Šimková, H. Jandíková, A. Pařízek, L. Stárka, M. Dušková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false