Markers of Oxidative Stress in Diabetic Mothers and Their Infants During Delivery

Title:

Markers of Oxidative Stress in Diabetic Mothers and Their Infants During Delivery

Creator:

Rajdl, D., Racek, J., Steinerová, A., Novotný, Z., Stožický, F., Trefil, L., and Siala, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:492d4b8b-ab8b-4070-ae12-546cecde1cec
uuid:492d4b8b-ab8b-4070-ae12-546cecde1cec

Subject:

Diabaetes mellitus, Gestational diabetes mellitus, Delivery, Oxidative stress, and Gender

Type:

article, model:article, and TEXT

Description:

Oxidative stress is probably a pathophysiological process leading to disadvantageous outcomes in diabetic pregnancies. We aimed to map a complex of potential markers of oxidative stress in this condition. Diabetic mothers had significantly higher concentrations of thiobarbituric acid reactive substances in the plasma [TBARS] both before (p<0.0001) and after (p<0.001) delivery and also their newborns showed higher values of TBARS (p<0.0001) in comparison with the control group. Diabetic mothers also showed lower concentrations of reduced glutathione in erythrocytes [GSH] both before (p<0.05) and after (p<0.01) delivery and their infants also had lower levels of GSH (p<0.0001). We found a lower total antioxidative capacity of plasma [AOC] before delivery (p<0.05) in the diabetic group in comparison with the control group. Newborns of diabetic mothers had higher plasmatic concentrations of apolipoproteine B [apo B] (p<0.05), higher erythrocyte glutathione peroxidase [GPx] activity (p<0.05) and lower pH (p<0.001) in the umbilical cord blood, when compared with infants of control non-diabetic mothers. We conclude that pregestational and gestational diabetes mellitus represent increased oxidative stress for both mother and her infant. TBARS in plasma are a valuable marker of oxidative stress in this condition. Disruption of glutathione peroxidase/glutathione pattern can be involved in pathophysiology of enhanced oxidative stress in diabetic pregnancies.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:4

Harvested from:

CDK

Metadata only:

false