The A-204C Polymorphism in the Cholesterol 7α-hydroxylase (CYP7A1) Gene Determines the Cholesterolemia Responsiveness to a High-Fat Diet

Title:

The A-204C Polymorphism in the Cholesterol 7α-hydroxylase (CYP7A1) Gene Determines the Cholesterolemia Responsiveness to a High-Fat Diet

Creator:

Kovář, J., Suchánek, P., Hubáček, J.A., and Poledne, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:481901cd-21af-456e-a4f7-7391250cc180
uuid:481901cd-21af-456e-a4f7-7391250cc180

Subject:

LDL-cholesterol, Cholesterol 7 alfa-hydroxylase, Diet responsiveness, and Genetics

Type:

article, model:article, and TEXT

Description:

The aim of the study was to ascertain whether the A-204C polymorphism in the cholesterol 7alfa-hydroxylase (CYP7A1) gene plays any role in determining LDL-cholesterol (LDL-C) concentration responsiveness to a high-fat diet. The concentrations of total cholesterol and LDL-cholesterol were measured in eleven healthy men (age: 30.9±3.2 years; BMI: 24.9±2.7 kg/m2) who were homozygous for either the -204A or -204C allele, after 3 weeks on a low-fat (LF) diet and 3 weeks on a high-fat (HF) diet. During both dietary regimens, the isocaloric amount of food was provided to volunteers; LF diet contained 22 % of energy as a fat and 2.2 mg of cholesterol/kg of body weight a day, HF diet 40 % of fat and 9.7 mg of cholesterol/kg of body weight a day. In six subjects homozygous for the -204C allele, the concentrations of cholesterol and LDL-cholesterol were significantly higher on HF than on LF diet (cholesterol: 4.62 vs. 4.00 mmol/l, p<0.05; LDL-C: 2.15 vs. 1.63 mmol/l, p<0.01, respectively); no significant change was observed in five subjects homozygous for the -204A allele. There were no other differences in lipid and lipoprotein-lipid concentrations. Therefore, the polymorphism in the cholesterol 7α-hydroxylase promotor region seems to be involved in the determination of cholesterol and LDL-C responsiveness to a dietary fat challenge.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:5

Harvested from:

CDK

Metadata only:

false