Effect of cervical sympathetic trunk transection on renal sympathetic nerve activity in rats

Title:

Effect of cervical sympathetic trunk transection on renal sympathetic nerve activity in rats

Creator:

Ikeda, Takehiko, Hirakawa, H., Kemuriyama, T., Nishida, Y., and Kazama, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:47664c29-d4c5-4721-a77a-812b00436834
uuid:47664c29-d4c5-4721-a77a-812b00436834

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, ganglia, krysa obecná, physiology, Rattus rattus, hvězdicová uzlina, stellate ganglion, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Stellate ganglion blockade (SGB) with a local anesthetic increases muscle sympathetic nerve activity in the tibial nerve in humans. However, whether this sympathetic excitation in the tibial nerve is due to a sympathetic blockade in the neck itself, or due to infiltration of a local anesthetic to adjacent nerves including the vagus nerve remains unknown. To rule out one mechanism, we examined the effects of cervical sympathetic trunk transection on renal sympathetic nerve activity (RSNA) in anesthetized rats. Seven rats were anesthetized with intraperitoneal urethane. RSNA together with arterial blood pressure and heart rate were recorded for 15 min before and 30 min after left cervical sympathetic trunk transection. The baroreceptor unloading RSNA obtained by decreasing arterial blood pressure with administration of sodium nitroprusside was also measured. Left cervical sympathetic trunk transection did not have any significant effects on RSNA, baroreceptor unloading RSNA, arterial blood pressure, and heart rate. These data suggest that there was no compensatory increase in RSNA when cervical sympathetic trunk was transected and that the increase in sympathetic nerve activity in the tibial nerve during SGB in humans may result from infiltration of a local anesthetic to adjacent nerves rather than a sympathetic blockade in the neck itself., T. Ikeda ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:1

Harvested from:

CDK

Metadata only:

false