Increased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea

Title:

Increased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea

Creator:

Brúsik, M., Štrbová, Z., Petrášová, D., Pobeha, P., Kuklišová, Z., Tkáčová, R., and Joppa, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:46332784-2823-44e0-a2b4-425996adc3a6
uuid:46332784-2823-44e0-a2b4-425996adc3a6

Subject:

Obstructive sleep apnoea, Resting energy expenditure, Obesity, and Insulin resistance

Type:

article, model:article, and TEXT

Description:

Obstructive sleep apnoea (OSA) has been associated with disturbances in energy metabolism and insulin resistance,nevertheless, the links between OSA severity, resting energy expenditure (REE) and insulin resistance (homeostasis model assessment, HOMA-IR) remained unexplored Therefore, we investigates the effects of OSA severity on REE, and relationships between REE and HOMA-IR in patients with OSA. Forty men[mean (SD) age 49.4 (11.4) years] underwent overnight polysomnography; REE was assessed using indirect calorimetry. REE adjusted for fat -free mass (FFM) was higher in patients with moderate-to severe OSA [n=24; body mass index (BMI) 31.1(2.7) kg.m-2; apnoea-hypopnoea index (AHI) ≥15 episodes.h-1] compared to participants with no clinically significant OSA(n=16; BMI 30.3 (2.2) kg.m-2; AHI<15 episodes.h-1) [median (interquartile range) 30.4 (26.1-31.3) versus 25.8 (24.6-27.3) kcal.kg-1.24 h-1, p=0.005)]. AHI and oxygen desaturation index(ODI) were directly related to REE/FFM (p=0.001; p<0.001, respectively) and to HOMA-IR (p<0.001 for both). In stepwise multiple linea models,REE/FFM was independently predicted by ODI (p<0.001) and age(p=0.028) (R2=0.346); HOMA-IR wasindependently predicted by ODI only (p<0.001,R2=0.457). In conclusion, male patients with moderate-to severe OSA haveincreased REE paralleled by impaired insulin sensitivity. Severity of nocturnal intermittent hypoxia reflected by ODI is an independent predictor of REE/FFM and HOMA-IR.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:6

Harvested from:

CDK

Metadata only:

false