Prediction of vertebral fractures by trabecular bone score in patients with ankylosing spondylitis

Title:

Prediction of vertebral fractures by trabecular bone score in patients with ankylosing spondylitis

Creator:

Killinger, Zdenko, Kužma, Martin, Tomková, Soňa, Brázdilová, Kristína, Jackuliak, Peter, and Payer, Juraj

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4543a1ce-872a-4b41-a0a0-c886603c34c6
uuid:4543a1ce-872a-4b41-a0a0-c886603c34c6
issn:0862-8408
doi:10.33549/physiolres.934774

Subject:

fyziologie člověka, kosti, human physiology, bones, Trabecular bone score, Vertebral fractures, Ankylosing spondylitis, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Ankylosing spondylarthritis (AS) is associated falsely increased lumbar spine bone mineral density (BMD). New tool for discrimination of subjects at fracture risk is needed. Vertebral fracture (VF) prediction of routine methods for osteoporosis assessment, BMD and trabecular bone score (TBS), in patients with AS. Cross-sectional study of all AS patients regularly followed at the rheumatology outpatient clinics of two centers. All subjects undergone BMD measurement at lumbar spine (LS), total hip (TH) and femoral neck (FN) using Hologic® Horizon device. TBS at L1-4 in all subjects by TBS InSight® software were assessed. Vertebral fracture assessment (VFA) was performed using the lateral spine imaging IVA™ and graded using Genant semi-quantitative approach. 119 AS subjects (90 males/29 females), mean age 47.6 years were included in the study. In 20 patients 34 VFs were detected, from whom 7 patients had multiple fractures. Subjects with VF were older and had lower FN BMD, TBS in comparison to non-VF subjects. No differences in LS BMD, FN BMD or BASDAI between groups were observed. Among patients with VF only 3 had T-score less than -2.5 but 7 has TBS less than 1.23 which means highly degraded microarchitecture. AS patients with VF have lower TBS and FN BMD in comparison to non-VF subjects. In addition, TBS was able to detect 20 % more VFs than BMD. Therefore, TBS seems promising in VF discrimination among patients with AS., Zdenko Killinger, Martin Kužma, Soňa Tomková, Kristína Brázdilová, Peter Jackuliak, Juraj Payer., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S53-S60

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false