Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression

Title:

Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression

Creator:

Hubacek, Jaroslav A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:452cdd65-4169-4521-bf07-11d8cdad1cbc
uuid:452cdd65-4169-4521-bf07-11d8cdad1cbc
doi:10.33549/physiolres.934730

Subject:

genetics, population, polymorphism, susceptibility, SARSCoV-2, and COVID-19

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Genetic predispositions may influence geographical and interethnic differences in COVID-19 prevalence and mortality in affected populations. Of the many genes implicated in COVID-19 progression, a substantial number have no direct functional link on virus transfer/viability or on the host immune system. To address this knowledge deficit, a large number of in silico studies have recently been published. However, the results of these studies often contradict the findings of studies involving real patients. For example, the ACE2 has been shown to play an important role in regulating coronavirus entry into cells, but none of its variations have been directly associated with COVID19 susceptibility or severity. Consistently was reported that increased risk of COVID-19 is associated with blood group A and with the APOE4 allele. Among other genes with potential impacts are the genes for CCR5, IL-10, CD14, TMPRSS2 and angiotensinconverting enzyme. Variants within the protein-coding genes OAS1 and LZTFL1 (transferred to the human genome from Neanderthals) are understood to be among the strongest predictors of disease severity. The intensive research efforts have helped to identify the genes and polymorphisms that contribute to SARS-CoV-2 infection and COVID-19 severity.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S125-S134

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false