DNA repair: exploiting the fanconi anemia pathway as a potenital therapeutic target

Title:

DNA repair: exploiting the fanconi anemia pathway as a potenital therapeutic target

Creator:

Tomáš Hucl and Gallmeier, E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:44b56ad0-baa9-40f3-8b10-69ab1682f48e
uuid:44b56ad0-baa9-40f3-8b10-69ab1682f48e

Subject:

Fyziologie člověka a srovnávací fyziologie, DNA (nukleová kyselina), fyziologie, deoxyribonucleic acid, physiology, DNA damage, DNA repair, fanconi anemia, synthetic lethality, targeted therapy, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

DNA repair is an active cellular process to respond to constant DNA damage caused by metabolic processes and environmental factors. Since the outcome of DNA damage is generally adverse and long term effects may contribute to oncogenesis, cells have developed a variety of DNA repair mechanisms, which operate depending on the type of DNA damage inflicted. At least 15 Fanconi anemia (FA) proteins interact in a common pathway involved in homologous recombination. Inherited homozygous mutations in any of these FA genes cause a rare disease, Fanconi anemia, characterized by congenit al abnormalities, progressive bone-marrow failure and cancer susceptibility. Heterozygous germline FA mutations predispose to various types of cancer. In addition, somatic FA mutations ha ve been identified in diverse cancer types. Evidence exists that cells deficient in the FA pathway become dependent on alternative pathways for survival. Additional inhibition of such alternative pathways is thus expected to result in cell death, creating a relationship of synthetic lethality. Identifying these relationships can reveal yet unknown mechanisms of DNA repair and new targets for therapy., T. Hucl, E. Gallmeier., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:3

Harvested from:

CDK

Metadata only:

false