Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats

Title:

Effects of long-term thyroid hormone level alterations, n-3 polyunsaturated fatty acid supplementation and statin administration in rats

Creator:

Tomáš Soukup

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3e262c69-9ce9-4642-9f65-7d1b8d778ee4
uuid:3e262c69-9ce9-4642-9f65-7d1b8d778ee4

Subject:

Fyziologie člověka a srovnávací fyziologie, hormony štítné žlázy, statiny, thyroid hormones, statins, n-3 polyunsaturated fatty acids (n-3 PUFA), rat muscle proteins, cardiac remodeling, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Thyroid hormones (THs) play multiple roles in the organism and alterations of their levels can result in many pathological changes. Currently, we use hypert hyroid and hypothyroid rats as “models of a diseased organi sm” and analyze whether n-3 polyunsaturated fatty acids (n-3 PUFA) administration can ameliorate TH-induced pathop hysiological changes. We investigate myosin heavy chain composition, calsequestrin levels, changes in cardiac tissue remodeling and cell-to-cell communication, expression of protein kinases, mitochondrial functions, oxidative stress mark ers and cell death, changes in serum lipid levels, activities of key enzymes of thyroid hormone metabolism, activity of acetyl choline esterase and membrane anisotropy, as well as mobile behavior and thermal sensitivity. Additionally we also mention our pilot experiments dealing with the effect of statin administration on skeletal muscles and sensory functions. As THs and n-3 PUFA possess multiple sites of potential action, we hope that our complex research will contribute to a better understanding of their actions, which can be useful in the treatment of di fferent pathophysiological events including cardiac insufficiency in humans., T. Soukup., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false