AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats

Title:

AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats

Creator:

Pavel Mareš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:39bf30e2-8d9c-463e-a0b4-e68978abdcec
uuid:39bf30e2-8d9c-463e-a0b4-e68978abdcec
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, epileptické záchvaty, ontogeneze, potkan, physiology, epileptic seizures, Rattus norvegicus, ontogeny, metabotropic glutamate receptors (mGlu Rs), uwanted motor efects, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Metabotropic glutamate receptors (mGluRs) represent a potential therapeutic target. Possible anticonvulsant action of AMN 082, an agonist of mGluR7 subtype, was studied in immature rats using pentylenetetrazol (PTZ)-induced seizures as a model. Five age groups of rats (7-, 12-, 18-, 25-day-old and adult animals) were pretreated with AMN 082 in doses of 0.5, 1, 2, and 5 mg/kg i.p. and 30 min later PTZ was administered (100 mg/kg s.c.). Controls received saline instead of the agonist. AMN 082 did not exhibit clear anticonvulsant action with the exception of suppression of the tonic phase of generalized tonic-clonic seizures (GTCS) in 12-day-old rats. Shorter latencies of GTCS after AMN 082 pretreatment indicate a proconvulsant action. Involuntary movements (mostly tremor) appeared after AMN 082 before PTZ administration, therefore we performed another experimental series with AMN 082 only (1, 2, 5, and 10 mg/kg i.p.). During 60-min observation period tremor appeared in all age groups; sensitivity to this action decreased with age from the 2 mg/kg dose in 7- and 12-day-old rats to the 10 mg/kg dose in adult rats. Mixed anti- and proconvulsant actions of AMN 082 together with unwanted motor effects makes clinical use of this drug highly improbable., Pavel Mareš., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:6

Harvested from:

CDK

Metadata only:

false