Diabetic macular edema-like ocular lesions in male spontaneously diabetic Torii Fatty Rats

Title:

Diabetic macular edema-like ocular lesions in male spontaneously diabetic Torii Fatty Rats

Creator:

Motohashi, Y., Kemmochi, Y., Maekawa, T., Tadaki, H., Sasase, T., Tanaka, Y., Kakehashi, A., Yamada, T., and Ohta, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:372077f2-d9f4-4d1e-bd3f-37693ca5409e
uuid:372077f2-d9f4-4d1e-bd3f-37693ca5409e
issn:0862-8408

Subject:

diabetická retinopatie, diabetic retinopathy, SDT fatty rat, VEGF, diabetic macular edema, retinal thickening, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Diabetic macular edema (DME) is a major factor contributing to visual disabilities in diabetic patients, and the number of patients is increasing. Animal models play a key role in the development of novel therapies. In this study, pathophysiological analyses of ocular lesions in Spontaneously Diabetic Torii (SDT) fatty rats were performed. First, vascular endothelial growth factor (VEGF) concentrations in vitreous humor, retinal vascular permeability and retinal thickness were measured in SDT fatty rats (Experiment 1). Furthermore, the pharmacological effects of two anti-diabetic drugs, phlorizin and pioglitazone, on retinal lesions were evaluated (Experiment 2). As results, the SDT fatty rats exhibited VEGF increase in vitreous humor at 8 and 16 weeks of age, and both retinal vascular hyperpermeability and retinal thickening at 16 weeks of age. In particular, the layers between the retinal internal limiting membrane and the outer nuclear layer were thickened. Phlorizin treatment from 4 to 16 weeks of age improved hyperglycemia and normalized retinal thickness; however, the effect of pioglitazone on retinal thickness was not strong despite the normalization of hyperglycemia. These data demonstrate that the male SDT fatty rat is a useful model for developing new therapeutic approaches in DME., Y. Motohashi, Y. Kemmochi, T. Maekawa, H. Tadaki, T. Sasase, Y. Tanaka, A. Kakehashi, T. Yamada, T. Ohta., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false