A new look at transudation: the apocrine connection

Title:

A new look at transudation: the apocrine connection

Creator:

Farkaš, Robert , Beňo, Milan , Beňová-Liszeková, Denisa , Raška, Ivan , and Raška, Otakar

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:366b97ee-60b3-4a55-8628-0c6fae9edc2c
uuid:366b97ee-60b3-4a55-8628-0c6fae9edc2c
doi:10.33549/physiolres.934229

Subject:

transcellular transport, vacuolation, endosome trafficking, vesicular cargo, exocytosis, apocrine secretion, transcytosis, and transudation

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Transcellular trafficking in which various molecules are transported across the interior of a cell, is commonly classified as transcytosis. However, historically this term has been used synonymously with transudation. In both cases transcellular trafficking starts with the internalization of proteins or other compounds on the basal or basolateral side of a cell and continues by their transport across the interior to the apical pole (or vice versa) where they are subsequently released. This allows a cell to release products which are synthesized elsewhere. Here, we discuss the common features of both transcytosis and transudation, and that which differentiates them. It appears that transcytosis and transudation are identical in terms of vesicular import and endosomal sorting of cargo, but completely differ in the re-secretion process. Specialized epithelial cells re-release substantial quantities of the endocytosed material, and often also a great variety. Some recent studies indicate that this is achieved by non-canonical apocrine secretion rather than by the regular vesicular mechanism of exocytosis, and takes place only on the apical pole. This massive re-release of endocytosed proteins, and potentially other compounds via the apocrine mechanism should be considered as transudation, distinct from transcytosis.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

227-244

Source:

Physiological research | 2020 Volume:69 | Number:2

Harvested from:

CDK

Metadata only:

false