Absence of flow-mediated vasodilation in the rabbit femoral artery

Title:

Absence of flow-mediated vasodilation in the rabbit femoral artery

Creator:

Clifford, P. S., Madden, J. A., Hamann, J. J., Buckwalter, J. B., and Valic, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:346763fc-5541-4378-b9b4-9e6dbb0b051e
uuid:346763fc-5541-4378-b9b4-9e6dbb0b051e

Subject:

Fyziologie člověka a srovnávací fyziologie, endotel, svaly, endothelium, muscles, blood flow, conduit vessel, skeletal muscle, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The purpose of this study was to determine if there is flowmediated vasodilation of the femoral artery in response to progressive increases in flow within a physiological range observed in the in vivo experiments. Femoral artery blood flow was determined in conscious rabbits (n=5) using chronically implanted flowprobes. Resting blood flow was 8.3±0.6 ml/min and increased to 39.9±5.4 ml/min during high intensity exercise. Femoral arteries (n=12, 1705±43 μm outer diameter) harvested from a separate group of rabbits were mounted on cannulas and diameter was continuously monitored by video system. Functional integrity of the endothelium was tested with acetylcholine. The arteries were set at a transmural pressure of 100 mm Hg and preconstricted with phenylephrine to 73±3 % of initial diameter. Using a roller pump with pressure held constant, the arteries were perfused intraluminally with warmed, oxygenated Krebs' solution (pH=7.4) over a physiological range of flows up to 35 ml/min. As flow increased from 5 ml/min to 35 ml/min, diameter decreased significantly (p<0.05) from 1285±58 μm to 1100±49 μm. Thus, in vessels with a functional endothelium, increasing intraluminal flow over a physiological range of flows produced constriction, not dilation. Based on these results, it seems unlikely that flow-mediated vasodilation in the rabbit femoral artery contributes to exercise hyperemia., P. S. Clifford ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:3

Harvested from:

CDK

Metadata only:

false