Alterations in Calcium Homeostasis as Biological Marker for Mild Alzheimer´s Disease?

Title:

Alterations in Calcium Homeostasis as Biological Marker for Mild Alzheimer´s Disease?

Creator:

Řípová, D., Platilová, V., Strunecká, A., Jirák, |R., and Höschl, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:33c1420a-59f6-4927-98a8-2ab90c312f55
uuid:33c1420a-59f6-4927-98a8-2ab90c312f55

Subject:

Alzheimer's disease, Vascular dementia, Platelets, Calcium homeostasis, and Biological marker

Type:

article, model:article, and TEXT

Description:

The calcium hypothesis of neurodegenerative disorders such as Alzheimer´s disease (AD) suggests that altered cytosolic Ca2+ levels ([Ca2+]i) and/or disturbances in Ca2+ homeostasis concern cellular mechanisms underlying neuronal pathology. To search for a diagnostic marker of Alzheimer´s disease, we measured cytosolic calcium concentrations in platelets of AD patients, age-matched control subjects (AMC), and vascular dementia (VD) patients. The ([Ca2+]i) was determined using long wavelength indicator Fluo-3AM in 21 mild AD patients, 17 AMC, and 23 patients with VD. The basal values of [Ca2+]i were significantly lower in AD compared to AMC. After the addition of 1 mM calcium, the [Ca2+]i markedly increased in platelets of AD compared to AMC and VD. Measurement of calcium homeostasis could provide a very sensitive, but less specific biological marker of AD. These results support the hypothesis that influencing calcium homeostasis may provide a therapeutic strategy in dementia.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:4

Harvested from:

CDK

Metadata only:

false