The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen

Title:

The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen

Creator:

Jovčić, Gordana, Bugarski, D., Krstić, A., Vlaški, M., Petakov, M., Mojsilović, S., Stojanović, N., and Milenković, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:33bbb7ec-d218-4f66-aa5d-7fbd4ecb8f7c
uuid:33bbb7ec-d218-4f66-aa5d-7fbd4ecb8f7c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie živočichů, krvetvorné kmenové buňky, slezina, cytokiny, animal physiology, hematopoietic stem cells, spleen, cytokines, interleukin, mouse spleen, cytokine release, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h after treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs., G. Jovčić, D. Bugarski, A. Krstić, M. Vlaški, M. Petakov, S. Mojsilović, N. Stojanović, P. Milenković., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:3

Harvested from:

CDK

Metadata only:

false