Increased diameter and enhanced myogenic response of saphenous vein induced by two-week experimental orthostasis are reversible

Title:

Increased diameter and enhanced myogenic response of saphenous vein induced by two-week experimental orthostasis are reversible

Creator:

Raffai, G., Lódi, C., Illyés, G., Nádasy, G., and Monos, E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:33a29630-dcec-41ec-a551-e2aff1501c7e
uuid:33a29630-dcec-41ec-a551-e2aff1501c7e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, endotel, hladké svaly, physiology, endothelium, smooth muscles, head-up tilt, saphenous vein, vascular responses, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Previously, increased diameter and enhanced myogenic tone were seen after 2-week 45º head-up (HUT2) in the rat. We studied the reversibility and the effect of extended tilt on this phenomenon using two experimental groups: HUT2 plus 2-week horizontal (HUT2HOR2), and 4-week tilting (HUT4). 4-weeks in normal cages (NC4) served as control. Diameter of saphenous vein (SV) in 2-20 mm Hg pressure range, wall and media thickness, endothelial and smooth muscle cell densities, and cell proliferation were measured. The diameter of SV from HUT4 was significantly larger compared with HUT2HOR2 or NC4 within the whole pressure range both in Krebs-Ringer (870.4±21.3 vs. 778.2±24.9 and 771.6±28.1 μm at 10 mm Hg, respectively) and in Ca2+-free solution. Myogenic and norepinephrine-induced vascular tone, wall and media thickness did not differ among the three groups. Endothelial cell density decreased in HUT4 (10.7±1.2) vs. HUT2HOR2 (15.1±1.0) and NC4 (15.3±0.6), while that of smooth muscle was unchanged. No cell proliferation marker was seen. In conclusion, both increased diameter and enhanced myogenic tone of SV seen in HUT2 proved to be reversible. HUT4 resulted in increased SV diameter, similarly to HUT2, however, vascular tone was not amplified. This suggests that a prolonged orthostatic load may readjust the function of smooth muscle., G. Raffai, C. Lódi, G. Illyés, G. Nádasy, E. Monos., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:2

Harvested from:

CDK

Metadata only:

false