Disodium cromoglycate attenuates hypoxia induced enlargement of end-expiratory lung volume in rats

Title:

Disodium cromoglycate attenuates hypoxia induced enlargement of end-expiratory lung volume in rats

Creator:

Hana Maxová, Hezinová, A., and Martin Vízek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2f88383d-d8d3-4cec-bf44-57b83e5d9474
uuid:2f88383d-d8d3-4cec-bf44-57b83e5d9474

Subject:

Fyziologie člověka a srovnávací fyziologie, patologická fyziologie, hypoxie, pathopsychology, hypoxia, chronic hypoxia, end-expiratory lung volume, tissue remodeling, mast cells, disodium cromoglycate, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Mechanism responsible for the en largement of end-expiratory lung volume (EELV) induced by chronic hypoxia remains unclear. The fact that the increase in EELV persists after return to normoxia suggests involvement of morphological changes. Because hypoxia has been also show n to activate lung mast cells, we speculated that th ey could play in the mechanism increasing EELV similar role as in vessel remodeling in hypoxic pulmonary hypertension (HPH). We, therefore, tested an effect of mast cells degranulation blocker disodium cromoglycate (DSCG) on hypoxia induced EELV enlargement. Vent ilatory parameters, EELV and right to left heart weight ratio (RV/LV+S) were measured in male Wistar rats. The experimental group (H+DSCG) was exposed to 3 weeks of normobaric hypoxia and treated with DSCG during the first four days of hypoxia, control group was exposed to hypoxia only (H), two others were kept in normoxia as non-treated (N) and treated (N+DSCG) groups. DSCG treatment significantly attenuated the EELV enlargement (H+DSCG=6.1 ± 0.8; H=9.2 ± 0.9; ml ± SE) together with the increase in minute ventilation (H+DSCG=190 ± 8; H=273 ± 10; ml/min ± SE) and RV/LV+S (H+DSCG=0.39 ± 0.03; H=0.50 ± 0.06)., H. Maxová, A. Hezinová, M. Vízek., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:5

Harvested from:

CDK

Metadata only:

false