Effect of different types of dietary fatty acids on subclinical inflammation in humans

Title:

Effect of different types of dietary fatty acids on subclinical inflammation in humans

Creator:

Králová Lesná, I., Suchánek, P., Brabcová, E., Jan Kovář, Hana Malínská, and Rudolf Poledne

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2d5c125e-25fc-4159-bad7-6bc90c507fc6
uuid:2d5c125e-25fc-4159-bad7-6bc90c507fc6

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, diet, unsaturated fatty acids, saturated fatty acids, inflammation, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Replacing SAFAs (saturated fatty acids) for vegetable PUFAs (polyunsaturated fatty acids) has a well documented positive effect on the lipoprotein pattern while the direct effect of dietary fatty acids composition on systemic inflammation remains to be proven. In well controlled randomised cross-over study with 15 overweight/obese postmenopausal women, the effect of dietary switch on systemic inflammation was investigated. A two 3 weeks dietary period either with predominant animal fat (SAFA, 29 caloric % SAFA) or vegetable fat (PUFA 25 % caloric % PUFA) were interrupted by wash-out period. The expected increasing effect on SAFA diet to LDL-C (low density cholesterol) and opposite effect of PUFA diet was documented following changes in fatty acid spectrum in VLDL (very low density cholesterol) particles. The switch from SAFA diet to PUFA diet produced a significant change of CRP (C-reactive protein) concentration (p<0.01) whereas similar trend of IL-18 did not reach statistical significance. In this study, previous in vitro results of different SAFA and PUFA proinflammatory effects with well documented molecular mechanisms were first proven in a clinical study. It could be stated that the substantial change of dietary fatty acid composition might influence proinflammatory effect in addition to traditional cardiovascular risk factors., I. Králová Lesná, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:2

Harvested from:

CDK

Metadata only:

false