Acute elevation of endogenous prolactin does not influence glucose homeostasis in healthy men

Title:

Acute elevation of endogenous prolactin does not influence glucose homeostasis in healthy men

Creator:

Vigaš, M., Klimeš, I., Jurčovičová, J., and Ježová, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2bdf9ca3-c9f2-46bd-abfa-9934919b679b
uuid:2bdf9ca3-c9f2-46bd-abfa-9934919b679b

Subject:

plasma prolactin, glucose, C-peptide, insulin, and insulin receptors

Type:

article, model:article, and TEXT

Description:

The diabetogenic effect of prolactin observed in patients with pathological hyperprolactinaemia was verified in healthy subjects. Plasma prolactin elevation was induced by administration of a dopamine antagonist drug domperidone (Motilium 10 mg orally, 9 subjects) and 2 h later the oral glucose tolerance test was performed. The influence of dopamine receptor stimulation on glucose homeostasis was tested by dopamine infusion (0.3 mg in saline or 20 % glucose, 1 g/min for 60 min, 11 subjects). After the blockade of dopamine receptors, a significant and prolonged increase of prolactin concentration was found. However, the levels of glucose, insulin, and C- peptide either before or after the glucose load were not different from control ones. The decreased number of insulin receptors (1.97±0.41 vs 0.51 ±0.14 pmol per 2.109 red blood cells) was compensated by increased affinity (0.51 ±0.17 vs 1.00±0.22 K* 108 mol.-1 per 1]) of insulin receptors. The stimulation of dopamine receptors showed a negligible effect on glucose regulation. It may be suggested that an endogenous increase of prolactin concentration in the physiological range does not participate in the regulation of glucose homeostasis in healthy subjects.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1993 Volume:42 | Number:5

Harvested from:

CDK

Metadata only:

false