First Bosnian study of the relatonship between APOE rs7412 and rs429358 variants and pregnancy loss

Title:

First Bosnian study of the relatonship between APOE rs7412 and rs429358 variants and pregnancy loss

Creator:

Adler, G., Mahmutbegovic , E., Uzar, I., Adler, M. A., Mahmutbegovic, N., and Valjevac, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:2b8180dc-032a-429d-a066-5f00ec2692d2
uuid:2b8180dc-032a-429d-a066-5f00ec2692d2

Subject:

gene variants, Bosnian women, miscarriage, and real-time PCR

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Due to inconsistent results of APOE variants in the survival of pregnancy we investigated the potential relationship of APOE rs7412 and rs429358 with pregnancy loss (PL) in Bosnian women. We enrolled 154 women with PL. The minimum week of miscarriage was 6, while the maximum was 28. As a control group, an equal number of mothers with at least one live-born child was included. All women were recruited from the Institution of Health Protection of Women and Motherhood in Sarajevo, Bosnia and Herzegovina. Genotyping was performed by re-al-time PCR at the Department of General Pha-macology and Pharmacoeconomics, Pomeranian Medical University. The prevalence of genotypes E2/E3, E2/E4, E3/E3, E3/E4, E4/E4 in the group with and without PL were: 14.3 %, 1.3 %, 70.8 %, 12.3 %, 1.3 %, and 13.6 %, 1.3 %, 70.1 %, 14.3 %, 0.7 %, respectively. The frequency of the E4/E4 genotype in women with 1–2 and 3–4 PL compared to women without PL did not differ significantly between those three groups (P value = 0.0712). The frequencies of alleles ԑ2, ԑ3, ԑ4 in the group with and without PL, were: 6.8 %, 85.1 %, 8.1 % and 7.5 %, 84.1 %, 8.4 %, respectively, and did not differ significantly. We conclude that our study does not confirm rs7412 and rs429358 as a potential risk factor for PL in the studied group. To elucidate the relationship between PL and variants of the APOE gene, studies with a larger sample size and placental histomorphology and ge-netic diagnosis are required. and Corresponding author: Grażyna Adler

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

[65]-69

Source:

Folia biologica | 2018 Volume:64 | Number:2

Harvested from:

CDK

Metadata only:

false