Exploratory behavior and recognition memory in medial septal electrolytic, neuro- and immunotoxic lesioned rats

Title:

Exploratory behavior and recognition memory in medial septal electrolytic, neuro- and immunotoxic lesioned rats

Creator:

Dashniani, M. G., Burjanadze, M. A., Naneishvili, T. L., Chkhikvishvili, N. C., Beselia, G. V., Kruashvili, L. B., Pochkhidze, N. O., and Chighladze, M. R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:29972ddb-5ee2-443f-9b45-69b8eac6e69b
uuid:29972ddb-5ee2-443f-9b45-69b8eac6e69b
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, paměť, memory, septohippocampal projections, recognition memory, exploratory behavior, open field, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

a1_In the present study, the effect of the medial septal (MS) lesions on exploratory activity in the open field and the spatial and object recognition memory has been investigated. This experiment compares three types of MS lesions: electrolytic lesions that destroy cells and fibers of passage, neurotoxic -ibotenic acid lesions that spare fibers of passage but predominantly affect the septal noncholinergic neurons, and immunotoxin - 192 IgG -saporin infusions that only eliminate cholinergic neurons. The main results are: the MS electrolytic lesioned rats were impaired in habituat ing to the environment in the repeated spatial environment, but rats with immuno - or neurotoxic lesions of the MS did not differ from control ones; the MS electrolytic and ibotenic acid lesioned rats showed an increase in their exploratory activity to the objects and were impaired in habituating to the objects in the repeated spatial environment; rats with immunolesions of the MS did not differ from control rats; electrolytic lesions of the MS disrupt spatial recognition memory; rats with immuno - or neurotoxic lesions of the MS were normal in detecting spatial novelty; all of the MS - lesioned and control rats clearly reacted to the object novelty by exploring the new object more than familiar ones. Results observed across lesion techniques indicate that: (i) the deficits after nonselective damage of MS are limited to a subset of cognitive processes dependent on the hippocampus, (ii) MS is substantial for spatial, but not for object recognition memory - the object recognition memory can be supported outside the septohippocampal system; (iii) the selective loss of septohippocampal cholinergic or noncholinergic projections does not disrupt the function of the hippocampus to a sufficient extent to impair spatial recognition memory;, a2_(iv) there is dissociation between the two major components (cholinergic and noncholinergic) of the septohippocampal pathway in exploratory behavior assessed in the open field - the memory exhibited by decrements in exploration of repeated object presentations is affected by either electr olytic or ibotenic lesions, but not saporin., M. G. Dashniani, M. A. Burjanadze, T. L. Naneishvili, N. C. Chkhikvishvili, G. V. Beselia, L. B. Kruashvili, N. O. Pochkhidze, M. R. Chighladze., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:5

Harvested from:

CDK

Metadata only:

false