Phospholipid content and fatty acid composition in the rat heart after chronic diazepam treatment

Title:

Phospholipid content and fatty acid composition in the rat heart after chronic diazepam treatment

Creator:

Ristić, V., Tepšić, V., De Luka, S. R., and Vrbaški, S. R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1ff713f4-24bd-47fb-ae6b-330451651b4f
uuid:1ff713f4-24bd-47fb-ae6b-330451651b4f

Subject:

phospholipid, fatty acids, heart, rat, and diazepam

Type:

article, model:article, and TEXT

Description:

The effects of chronic diazepam treatment (10 mg/kg/day for 180 days) on the fractional distribution and fatty acid composition of heart phospholipids were studied in male Wistar rats. It was found that diazepam treatment increased the content of phosphatidylcholine and cardiolipin in the heart and slightly increased its phosphatidylcholine fraction. There were no significant changes in fatty acid composition after diazepam treatment in heart phospholipids, with the exception of significant decrease of 20:3n-6 and 20:5n-3 fatty acids. Our findings suggest that diazepam, probably through peripheral benzodiazepine binding sites, altered the content of heart cardiolipin and caused changes in the flux of oxidative phosphorylation in the heart.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:2

Harvested from:

CDK

Metadata only:

false