Possible pathogenetic mechanisms and new therapeutic approaches of pes equinovarus

Title:

Possible pathogenetic mechanisms and new therapeutic approaches of pes equinovarus

Creator:

Miroslav Ošťádal, Lišková, J., Hadraba, D., and Adam Eckhardt

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1f404be2-fba7-407e-9f48-713d1dd37249
uuid:1f404be2-fba7-407e-9f48-713d1dd37249
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, pes equinovarus, clubfoot, pathogenetic mechanisms, fibrosis, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Idiopathic pes equinovarus (clubfoot) is a congenital deformity of the foot and lower leg defined as a fixation of the foot in plantar flexion, adduction, supination and varus. The deformity does not affect only the foot position, which is usually investigated by radiography, CT, micro-CT, MRI or ultrasound but logically influence the whole gait biomechanics. It is supposed, that clubfoot belongs to a group of fibroproliferative disorders whose origin and multi- hierarchical effect remain unknown. It has been suggested that fibroblasts and growth factors may be involved. To gain a more global view, direct analysis of the protein composition of extra cellular matrix, a proteomic approach was used. At present two principle methods are mostly used for the treatment of clubfoot: physiotherapy and the Ponseti method. The determination of the general biological and biomechanical parameters for various regio ns of the clubfoot can potentially help in the understanding of the mechanisms participating on this serious anomaly and thus contribute to the development of the more efficient therapeutic approach. This review summarizes the present knowledge on the poss ible pathogenetic mechanisms participating in the development of the clubfoot and their possible relation to the new therapeutic approaches., M. Ošťádal, J. Lišková, D. Hadraba, A. Eckhardt., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:3

Harvested from:

CDK

Metadata only:

false