The incidence of metabolic syndrome in obese czech children: the importance of early detection of insulin resistance using homeostatic indexes HOMA-IR and QUICKI

Title:

The incidence of metabolic syndrome in obese czech children: the importance of early detection of insulin resistance using homeostatic indexes HOMA-IR and QUICKI

Creator:

Dalibor Pastucha, Radka Filipčíková, Dagmar Horáková, Lenka Radová, Zlatko Marinov, Jana Malinčíková, Kocvrlich, M., Horák, S., Marcela Bezdičková, and Miloš Dobiáš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1ddcff86-38b2-4cf8-9120-4a4e02b8ec6a
uuid:1ddcff86-38b2-4cf8-9120-4a4e02b8ec6a

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, obesity, metabolic syndrome, HOMA-IR, QUICKI, children, adolescents, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Common alimentary obesity frequently occurs on a polygenic basis as a typical lifestyle disorder in the developed countries. It is associated with characteristic complex metabolic changes, which are the cornerstones for future metabolic syndrome development. The aims of our study were 1) to determine the incidence of metabolic syndrome (based on the diagnostic criteria defined by the International Diabetes Federation for children and adolescents) in Czech obese children, 2) to evaluate the incidence of insulin resistance according to HOMA-IR and QUICKI homeostatic indexes in obese children with and without metabolic syndrome, and 3) to consider the diagnostic value of these indexes for the early detection of metabolic syndrome in obese children. We therefore performed anthropometric and laboratory examinations to determine the incidence of metabolic syndrome and insulin resistance in the group of 274 children with obesity (128 boys and 146 girls) aged 9-17 years. Metabolic syndrome was found in 102 subjects (37 %). On the other hand, the presence of insulin resistance according to QUICKI <0.357 was identified in 86 % and according to HOMA-IR >3.16 in 53 % of obese subjects. This HOMA-IR limit was exceeded by 70 % children in the MS(+) group, but only by 43 % children in the MS(–) group (p<0.0001). However, a relatively high incidence of insulin resistance in obese children without metabolic syndrome raises a question whether the existing diagnostic criteria do not falsely exclude some cases of metabolic syndrome. On the basis of our results we suggest to pay a preventive attention also to obese children with insulin resistance even if they do not fulfill the actual diagnostic criteria for metabolic syndrome., D. Pastucha, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:3

Harvested from:

CDK

Metadata only:

false