Inhibition of NO synthase activity in nervous tissue leads to decreased motor activity in the rat

Title:

Inhibition of NO synthase activity in nervous tissue leads to decreased motor activity in the rat

Creator:

Lukáč Halčák, Oľga Pecháňová, Žigová, Z., Klemová, L., Novacký, M., and Iveta Bernátová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1d900d41-dca5-4473-a6f8-9289b30cbf67
uuid:1d900d41-dca5-4473-a6f8-9289b30cbf67
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, oxid dusnatý, nitric oxide, L-NAME, nervous tissue, spontaneous behavior, habituation tasks, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The nitric oxide/cGMP system has been shown to play a crucial role in the mechanism of learning and memory. The aim of the present study was to investigate whether the inhibition of NO synthase in brain regions leads to alterations of spontaneous behavior in rats. Male Wistar rats were treated with NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) at the dose of 40 mg/kg/day. After 4 weeks of L-NAME treatment, NO synthase activity was significantly decreased by 75 % in the cerebellum, by 71 % in the cerebral cortex and by 72 % in the thoracic spinal cord. Decreased NO synthase activity in the nervous tissue was associated with decreased motor horizontal and vertical activities as well as by lowered frequency of sniffing, cleaning and defecation. It is concluded that the inhibition of NO synthase activity has a suppressive effect on spontaneous behavior of rats., L. Halčák, O. Pecháňová, Z. Žigová, L. Klemová, M. Novacký, I. Bernátová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:1

Harvested from:

CDK

Metadata only:

false