Intrarenal gene expression of proinflammatory chemokines and cytokines in chronic proteinuric glomerulopathies

Title:

Intrarenal gene expression of proinflammatory chemokines and cytokines in chronic proteinuric glomerulopathies

Creator:

Irena Brabcová, Kotsch, K., Petra Hřibová, Loužecká, A., Kateřina Bartošová, Hyklová, K., Lácha, J., Volk, H.-D., and Ondřej Viklický

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:19173bd0-405c-4ad6-a068-6bcbe2e753bd
uuid:19173bd0-405c-4ad6-a068-6bcbe2e753bd
issn:0862-8408

Subject:

Patologie. Klinická medicína, nefrologie, glomerulonefritida, proteinurie, genová exprese, nephrology, glomerulonephritis, proteinuria, gene expression, chemokiny, chemokines, 14, and 616

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Proteinuria has been recently shown to be an independent risk factor for the progression of chronic nephropathies, but the actual mechanisms by which urinary protein load damages renal tissue in humans remain unsolved. Using real-time RT-PCR method we evaluated intrarenal mRNA expression of various cytokines and chemokines in patients with biopsy-proven IgA nephropathy (IgAN, n=11), membranous nephropathy (MN, n=6) and focal and segmental glomerulosclerosis (FSGS, n=6) who exhibited proteinuria over 0.5 g/day. There was a significant positive correlation between the proteinuria extent and the intrarenal RANTES (regulated upon activation normal T cell expressed and secreted) mRNA expression in patients with IgAN, a similar trend was also observed in patients with MN and FSGS. There were no clear relationships between the proteinuria and intrarenal mRNA expression of tumor necrosis factor α, transforming growth factor β1 and monocyte chemoattractant peptide-1. There were no differences in the pattern of cytokine mRNA expression between different glomerulopathies. In conclusion, our results support the hypothesis that lymphocytes, macrophages and their products provoke tissue in jury in response to proteinuria independently of the nature of renal diseases in man., I. Brabcová, K. Kotsch, P. Hřibová, A. Loužecká, K. Bartošová, K. Hyklová, J. Lácha, H.-D. Volk, O. Viklický., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:2

Harvested from:

CDK

Metadata only:

false