New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes

Title:

New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes

Creator:

Muelas, Susana, Di Maio, Rossanna, Cerecetto, Hugo, Seoane, Gustavo, Ochoa, Carmen, Escario, José Antonio, and Gómez-Barrio, Alicia

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1811aea9-7b21-420f-9e7f-926bec411702
uuid:1811aea9-7b21-420f-9e7f-926bec411702
doi:10.14411/fp.2001.015

Subject:

anti-Trypanosoma cruzi drugs, amastigotes, J774 macrophages, and cytotoxicity assay

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

The cytotoxicity of 18 new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides was evaluated. This group of products was previously assayed against epimastigotes of Trypanosoma cruzi and some of them showed a high antiprotozoal activity. Thereafter 13 compounds with a high anti-epimastigote activity and low cytotoxicity were selected to be assayed against amastigotes. Some of the products showed the same or even lower cytotoxicity than nifurtimox and benznidazole, but most of them were very toxic for macrophages at 100 µg/ml. Only one of the compounds had an anti-amastigote activity similar to that of reference drugs at 10 µg/ml, but unfortunately this disappeared at lower concentrations.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

105-108

Source:

Folia parasitologica | 2001 Volume:48 | Number:2

Harvested from:

CDK

Metadata only:

false