Tumor necrosis factor α in various tissues of insulin-resistant obese koletsky rats: relations to insulin receptor characteristics

Title:

Tumor necrosis factor α in various tissues of insulin-resistant obese koletsky rats: relations to insulin receptor characteristics

Creator:

Hřebíček, A., Rypka, M., Chmela, Z., Veselý, J., Magdaléna Kantorová, and Věroslav Golda

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:17722cc1-9caf-4d3f-8250-e2a22c31033f
uuid:17722cc1-9caf-4d3f-8250-e2a22c31033f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, tumor necrosis factor α, insulin resistance, insulin receptor protein tyrosine kinase activity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Tumor necrosis factor a (TNFa) was found to be significantly increased in skeletal muscles and retroperitoneal fat of obese insulin-resistant Koletsky rats as compared to control Wistar rats. This increase was accompanied by a depression of insulin receptor protein tyrosine kinase (PTK) activity. Neither the insulin-binding capacity nor insulin receptor affinity were related to this TNFa increase in these tissues. In the liver, no significant changes of TNFa content and only a lowering of insulin-binding capacity were found. It is concluded that an increased TNFa content in muscles and fat (but not in the liver) contributes to insulin resistance by lowering insulin receptor protein tyrosine kinase activity, while other insulin receptor characteristics (insulin-binding capacity and affinity of insulin receptors to the hormone) do not seem to be influenced by this factor., A. Hřebíček, M. Rypka, Z. Chmela, J. Veselý, M. Kantorová, V. Golda., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1999 Volume:48 | Number:1

Harvested from:

CDK

Metadata only:

false