Age-dependent changes in the function of mitochondrial membrane permeability transition pore in rat liver mitochondria

Title:

Age-dependent changes in the function of mitochondrial membrane permeability transition pore in rat liver mitochondria

Creator:

Endlicher, René, Drahota, Zdeněk, Kučera, Otto, and Červinková, Zuzana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:162eecaa-e1ca-4e56-b7ac-4715776b2164
uuid:162eecaa-e1ca-4e56-b7ac-4715776b2164
doi:10.33549/physiolres.934734

Subject:

rat liver mitochondria, mitochondrial permeability transition pore, calcium retention capacity, and calcium-induced swelling

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Mitochondria play an important role in the cell aging process. Changes in calcium homeostasis and/or increased reactive oxygen species (ROS) production lead to the opening of mitochondrial permeability transition pore (MPTP), depolarization of the inner mitochondrial membrane, and decrease of ATP production. Our work aimed to monitor age-related changes in the Ca2+ ion effect on MPTP and the ability of isolated rat liver mitochondria to accumulate calcium. The mitochondrial calcium retention capacity (CRC) was found to be significantly affected by the age of rats. Measurement of CRC values of the rat liver mitochondria showed two periods when 3 to 17-week old rats were tested. 3-week and 17-week old rats showed lower CRC values than 7-week old animals. Similar changes were observed while testing calcium-induced swelling of rat liver mitochondria. These findings indicate that the mitochondrial energy production system is more resistant to calcium-induced MPTP opening accompanied by the damaging effect of ROS in adult rats than in young and aged animals.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

905-911

Source:

Physiological research | 2021 Volume:70 | Number:6

Harvested from:

CDK

Metadata only:

false