Epigenetics and a new look on metabolic syndrome

Title:

Epigenetics and a new look on metabolic syndrome

Creator:

Jaroslav Kuneš, Ivana Vaněčková, Barbora Lapčíková, Michal Behuliak, Lenka Maletínská, and Josef Zicha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:161cfd9f-83a7-4b16-bf49-fae8a616f46d
uuid:161cfd9f-83a7-4b16-bf49-fae8a616f46d
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, hypertenze, ekologická genetika, obesity, hypertension, ecological genetics, metabolic syndrome, epigenetics, transgenerational inheritance, gene-environmental interactions, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The study of exact mechanisms is very complicated because both genetic and environmental factors contribute to this complex disease. The ability of environmental fac tors to promote phenotype changes by epigenetic DNA modifications (i.e. DNA methylation, histone modifications) was demonstrated to play an important role in the development and predisposition to particular symptoms of metabolic syndrome. There is no doubt that the early life, such as the fetal and perinatal periods, is critical for metabolic syndrome development and therefore critical for prevention of this disease. Moreover, these changes are visible not only in individuals exposed to environmental factor s but also in the subsequent progeny for multiple generations and this phenomenon is called transgenerational inheritance. The knowledge of molecular mechanisms, by which early minor environmental stimuli modify the expression of genetic information, might be the desired key for the understanding of mechanisms leading to the change of phenotype in adulthood. This review provides a short overview of metabolic syndrome epigenetics., J. Kuneš, I. Vaněčková, B. Mikulášková, M. Behuliak, L. Maletínská, J. Zicha., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:5

Harvested from:

CDK

Metadata only:

false