Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice

Title:

Effect of prior chronic aerobic exercise on overload-induced skeletal muscle hypertrophy in mice

Creator:

Siriguleng, Koike, T, Natsume, Y, Iwama, S, and Oshida, Y

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:15a0130b-e7c1-4e98-b1bf-bf4317453eb1
uuid:15a0130b-e7c1-4e98-b1bf-bf4317453eb1
issn:0862-8408

Subject:

svaly, muscles, aerobic exercise, skeletal muscle, hypertrophy, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

This study aimed to examine how regular aerobic training can affect the muscle hypertrophy induced by overloading. Male C57BL/6J mice were randomly divided into three groups: rest group, low-intensity aerobic exercise group, and high-intensity aerobic exercise group. Mice in the exercise groups were assigned to run at a speed of 10 m/min (low-intensity) or 25 m/min (high-intensity) for 30 min/day, five days/week, for four weeks. Then, the right hind leg gastrocnemius muscles were surgically removed to overload the plantaris and soleus muscles, while the left hind leg was subjected to a sham-operation. Both the plantaris and soleus muscles grew larger in the overloaded legs than those in the sham-operated legs. Muscle growth increased in the plantaris muscles in the low-intensity exercise group compared to that in the rest or high-intensity exercise groups at one and two weeks after overloading. This enhancement was not observed in the soleus muscles. Consistently, we observed changes in the expression of proteins involved in anabolic intracellular signaling, including Akt, mechanistic target of rapamycin (mTOR), and p70S6K, in the plantaris muscles. Our data showed for the first time that chronic low-intensity aerobic exercise precipitates overload-induced muscle growth., Siriguleng, T. Koike, Y. Natsume, S. Iwama, Y. Oshida., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false