Head-up tilt rapidly compromises hemodynamics in healthy anesthetized swine

Title:

Head-up tilt rapidly compromises hemodynamics in healthy anesthetized swine

Creator:

Mikuláš Mlček, Jan Bělohlávek, Michal Huptych, Tomáš Bouček, Belza, T., Lacko, S., Krupickova, P., Hrachovina, M., Popkova, M., Petr Neužil, and Otomar Kittnar

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1575d148-016d-49bb-a6fd-16852b677d9e
uuid:1575d148-016d-49bb-a6fd-16852b677d9e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hemodynamika, hemodynamics, head-up tilt, pressure-volume loop, cardiac output, swine, oximetry, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aims were to explore the effect of head-up tilt (HUT) to 30 and 60 degrees on hemodynamics and tissue oxygenation in anesthetized healthy swine. The data serve as a reference for a study of resuscitation efficacy at HUT such as during transport. Nine healthy swine (49±4 kg) were anesthetized and multiple sensors including myocardial pressure-volume loops catheter, carotid flow probe, blood pressure catheters, near infrared spectroscopy (NIRS) tissue oximetry and mixed venous oximetry (SVO2) catheter were introduced and parameters continuously recorded. Experimental protocol consisted of baseline in supine position (15 min), 30 degrees HUT (15 min), recovery at supine position (15 min) and 60 degrees HUT (5 min). Vacuum mattress was used for body fixation during tilts. We found that 30 and 60 degrees inclination led to significant immediate reduction in hemodynamic and oximetry parameters. Mean arterial pressure (mm Hg) decreased from 98 at baseline to 53 and 39, respectively. Carotid blood flow dropped to 47 % and 22 % of baseline values, end diastolic volume to 49 % and 53 % and stroke volume to 47 % and 45 % of baseline. SVO2 and tissue oximetry decreased by 17 and 21 percentage points. The values are means. In conclusions, within minutes, both 30 and 60 degrees head-up tilting is poorly tolerated in anesthetized swine. Significant differences among individual animals exist., M. Mlcek, J. Belohlavek, M. Huptych, T. Boucek, T. Belza, S. Lacko, P. Krupickova, M. Hrachovina, M. Popkova, P. Neuzil, O. Kittnar., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 5

Harvested from:

CDK

Metadata only:

false