The labile iron pool in monocytes reflects the activity of the atherosclerotic process in men with chronic cardiovascular disease

Title:

The labile iron pool in monocytes reflects the activity of the atherosclerotic process in men with chronic cardiovascular disease

Creator:

Riško, P., Jan Pláteník, Buchal, R., Jana Potočková, and Kraml, P. J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:12a328ce-b48f-4ffd-94f6-2f37e017f0a3
uuid:12a328ce-b48f-4ffd-94f6-2f37e017f0a3
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, záněty, inflammations, iron overload, monocytes, arterial stiffness, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The study investigates the relationship between the labile iron pool (LIP) in circulating monocytes and markers of iron metabolism, inflammation, oxidative stress, endothelial dysfunction and arterial elasticity in patients with chronic cardiovascular disease and in healthy volunteers. The patie nts with a history of CVEs had significantly higher LIP values tha n did the control group (1.94± 0.46 μM vs. 1.62 ±0.49 μM, p=0.02). Except for the leukocyte number (WBCs), the groups did not differ in other inflammatory markers (CRPus, CD 163, MPO, MMP-1). Similarly, there were no differences in the markers of endothelial dysfunction (ICAM, VCAM, E-selectin, vWF). The CVE group had higher pulse pressures, levels of markers of impaired arterial elasticity (AI, Young's modulus, pulsatility, stiffness index), I MT values and ABI values. The LIP concentration was significantly correlated with the transferrin receptor⁄ferritin ratio, hepcidin levels, VFT content and the ABI and ET values. Patients with a history of CVE have significantly higher concentrations of ir on in their intracellular LIP in circulating monocytes than do healthy controls. The independent and significant correlation of LIP with markers of the progression of atherosclerosis and arterial stiffness suggests LIP as a possible novel marker of atheros clerotic activity., P. Riško, J. Pláteník, R. Buchal, J. Potočková, P. J. Kraml., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:1

Harvested from:

CDK

Metadata only:

false