Ontogenetic profile of ecto-ATPase activity in rat hippocampal and caudate nucleus synaptic plasma membrane fractions

Title:

Ontogenetic profile of ecto-ATPase activity in rat hippocampal and caudate nucleus synaptic plasma membrane fractions

Creator:

Banjac, A., Nedeljković, N., Horvat, A., Dušan Kanazir, and Nikezić, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:125b1820-6bc6-4fb4-9055-ee1d34958ff0
uuid:125b1820-6bc6-4fb4-9055-ee1d34958ff0
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, stárnutí, mozek, aging, brain, ecto-ATPase, extracellular purines, development, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

An ontogenetic study of ecto-ATPase activity and the content of enzyme proteins was assessed in the caudate nucleus and hippocampal synaptic plasma membranes isolated from rats at various ages (15, 30, 90, 180 and 365 days). The ontogenetic profile revealed that the enzyme activities in both brain areas were the highest on day 30 and 365, while the ecto-ATPase protein abundance was the highest on day 15 after birth. Possible explanation for obtained ontogenetic profile and the discrepancy between activity and abundance may reside in the fact that ecto-ATPase during development could exert additional roles other than those related to metabolism of ATP. It is likely that ecto-ATPase, regulating the concentration of ATP and adenosine in synaptic cleft, has important role in the processes of brain development and aging., A. Banjac, N. Nedeljković, A. Horvat, D. Kanazir, G. Nizekić., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:4

Harvested from:

CDK

Metadata only:

false